CAY10404
作者：齊岳
發(fā)布時(shí)間：2023-09-05
08:51:56
點(diǎn)擊數(shù)：
產(chǎn)品名稱：CAY10404
產(chǎn)品描述：
| 產(chǎn)品描述 | CAY10404 is a potent and highly selective inhibitor of COX-2 and COX-1. It is also a potent inhibitor of PKB/Akt and MAPK signalling pathways and induces apoptosis in NSCLC cells, with analgesic, anti-inflammatory and anti-cancer activities. |
| 靶點(diǎn)活性 | COX-2:1 nM, COX-1:>500 μM |
| 體外活性 | Treatment with CAY10404 in the range of 10-100 microM caused dose-dependent growth inhibition, with an average 50% inhibitory concentration (IC(50)) of 60-100 micromol/L, depending on the cell line.?Western blot analysis of CAY10404-treated cells showed cleavage of poly (ADP-ribose) polymerase (PARP) and procaspase-3, signifying caspase activity and apoptotic cell death.?CAY10404 treatment inhibited the phosphorylation of Akt, glycogen synthase kinase-3beta and extracellular signal-regulated kinases 1/2 in H460 and H358 cells[1] |
| 細(xì)胞實(shí)驗(yàn) | To measure the effects of CAY10404 on proliferation of NSCLC cells, 3 x 10(3) cells/well were plated in 96-well plates and allowed to adhere overnight at 37 degrees C. After treatment with CAY10404 for 3 days, cell proliferation was measured by the 3- (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. In the H460 NSCLC cells, evidence of apoptosis was sought using the terminal deoxynucleotidyl transferase deoxyuridine triphosphate (dUTP) nick end labelling (TUNEL) assay and western blot analysis[1]. |
| 別名 | 3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T |
| 分子量 | 367.34 |
| 分子式 | C17H12F3NO3S |
| CAS No. | 340267-36-9 |
存儲(chǔ)
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 10 mg/mL (27.22 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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