產(chǎn)品名稱：活性氧GPX4 Polyclonal Antibody，Glutathione Peroxidase 4，GSHPx-4，PhGPx

產(chǎn)品描述：

產(chǎn)品名稱：

活性氧GPX4 Polyclonal Antibody，Glutathione Peroxidase 4，GSHPx-4，PhGPx

產(chǎn)地：西安

規(guī)格：1mg 5mg 10mg

純度：99%

用途：僅用于科研

狀態(tài)：固體/粉末

儲(chǔ)藏條件：冷藏-20℃

溫馨提示：僅用于科研，不能用于人體實(shí)驗(yàn)！

說(shuō)明：提供使用說(shuō)明，核磁圖譜，包裝，價(jià)格，產(chǎn)地，制備方法，應(yīng)用，穩(wěn)定性，溶解度，簡(jiǎn)單合成等各種信息　　

Glutathione peroxidase 4 (GPX4) is a selenocysteine-containing glutathione peroxidase that is encoded by the GPX4 gene in humans and protects cellular membranes from oxidative damage.1,2 It is a monomeric protein consisting of a thioredoxin motif and a selenocysteine-glutamine-tryptophan catalytic triad that reduces lipid hydroperoxides, including phospholipid, polyunsaturated lipid, and sterol hydroperoxides, to non-toxic lipid alcohols. During this process, the active site selenocysteine becomes oxidized and must subsequently be replenished by the reducing substrate glutathione (GSH).2 There are three isoforms of GPX4, mitochondrial mGPX4, cytosolic cGPX4, and nuclear nGPX4/snGPX4, that are expressed in all tissue types in rats, with the highest mRNA levels observed in testes.1,2,3 GPX4 is a key regulator of ferroptosis that inhibits ferroptotic cell death by preventing iron-dependent accumulation of toxic lipid reactive oxygen species.2 Mutations in GPX4 have been found in patients with Sedaghatian-type spondylometaphyseal dysplasia (SSMD), and silencing of Gpx4 in mice is embryonic lethal.4,2 Cayman's GPX4 Polyclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications. The antibody recognizes GPX4 at 20 kDa from human, mouse, rat, and porcine samples.

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編輯：XAQYBIO HAO，2023年3月27日。

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西安齊岳生物科技有限公司是集化學(xué)科研和定制與一體的高科技化學(xué)公司。業(yè)務(wù)范圍包括化學(xué)試劑和產(chǎn)品的研發(fā)、生產(chǎn)、銷售等。涉及產(chǎn)品為通用試劑的分銷、非通用試劑的定制與研發(fā)，涵蓋生物科技、化學(xué)品、中間體和化工材料等領(lǐng)域。
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