活性氧Isorhynchophylline,6859-01-4
產(chǎn)品名稱:活性氧Isorhynchophylline,6859-01-4
產(chǎn)品描述:
產(chǎn)品名稱:活性氧Isorhynchophylline,6859-01-4
產(chǎn)地:西安
規(guī)格:1mg 5mg 10mg
純度:99%
用途:僅用于科研
狀態(tài):固體/粉末
儲藏條件:冷藏-20℃
溫馨提示:僅用于科研,不能用于人體實驗!
說明:提供使用說明,核磁圖譜,包裝,價格,產(chǎn)地,制備方法,應(yīng)用,穩(wěn)定性,溶解度,簡單合成等各種信息
Isorhynchophylline is an oxindole alkaloid that has been found in Uncaria and has diverse biological activities, including neuroprotective, anticancer, and antihypertensive properties.1,2,3,4 It inhibits decreases in cell viability and increases in intracellular levels of reactive oxygen species (ROS) and malondialdehyde (MDA) induced by amyloid-β (25-35) (Aβ (25-35); Item No. 24155) in PC12 cells in a concentration-dependent manner.1 Isorhynchophylline (30 and 100 μM) attenuates decreases in population spike amplitudes in the CA1 region of a rat hippocampal slice model of ischemia induced by oxygen and D-glucose deprivation.2 It decreases the viability of HepG2, A549, BxPC-3, Caki-1, RPMI-8226, and 786-O cells (IC50s = 130-292 μM).3 In HepG2 cells, isorhynchophylline induces apoptosis, inhibits cell migration in a wound healing assay, and decreases invasion in a Matrigel? assay. Isorhynchophylline (0.1% in the diet) decreases right ventricular end systolic pressure, hypertrophy, and fibrosis in a rat model of pulmonary arterial hypertension induced by monocrotaline (Item No. 16666).4
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編輯:XAQYBIO HAO,2023年3月27日。
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