活性氧6-OHDA (hydrobromide),636-00-0
產(chǎn)品名稱:活性氧6-OHDA (hydrobromide),636-00-0
產(chǎn)品描述:
產(chǎn)品名稱:
活性氧6-OHDA (hydrobromide),636-00-0
產(chǎn)地:西安
規(guī)格:1mg 5mg 10mg
純度:99%
用途:僅用于科研
狀態(tài):固體/粉末
儲(chǔ)藏條件:冷藏-20℃
溫馨提示:僅用于科研,不能用于人體實(shí)驗(yàn)!
說明:提供使用說明,核磁圖譜,包裝,價(jià)格,產(chǎn)地,制備方法,應(yīng)用,穩(wěn)定性,溶解度,簡單合成等各種信息
6-OHDA is a catecholaminergic neurotoxin that has been used to induce dopaminergic lesions and parkinsonian symptoms as a model of Parkinson's disease in rodents.1 It induces locomotor impairment in mice and loss of tyrosine hydroxylase-reactive neurons in mouse brain when administered into the substantia nigra, medial forebrain bundle (MFB), or striatum at doses of 9, 6, and 18 μg, respectively.2 Intracisternal administration of 6-OHDA (200 μg) decreases dopamine (Item No. 21992) and norepinephrine (Item No. 16673) levels in rat brain.3 It induces apoptosis in primary rat cortical cells and PC12 rat adrenal cells when used at a concentration of 50 μM.4,5 6-OHDA (75 μM) activates caspase-3, -8, and -9 in a time-dependent manner and increases the level of intracellular reactive oxygen species (ROS) in PC12 cells and induces apoptosis in rat substantia nigra when stereotaxically injected into the right MFB.5,6
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編輯:XAQYBIO HAO,2023年3月27日。
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