Piclidenoson
作者：齊岳
發(fā)布時(shí)間：2023-09-06
09:00:44
點(diǎn)擊數(shù)：
產(chǎn)品名稱：Piclidenoson
產(chǎn)品描述：
| 產(chǎn)品描述 | Piclidenoson, a selective agonist of adenosine A3 receptor(EC50 values of 0.11 μM), induces robust anti-inflammatory effect in psoriasis patients. |
| 體外活性 | Piclidenoson inhibited the proliferation of HaCat cells through deregulation of the NF-κB signaling pathway, leading to a decrease in interleukin-17 and interleukin-23 expression levels[1]. |
| 細(xì)胞實(shí)驗(yàn) | [3H]-Thymidine incorporation assay was used to evaluate cell growth.?HaCat cells (2500 cells/well) were incubated with piclidenoson 10?nM and MRS 1523 (50?nM) in 96-well plate for 48 hours.?For the last 24 hours of incubation, each well was pulsed with 1?mCi [3H]-thymidine.?Cells were harvested, and the [3H]-thymidine uptake was determined in an LKB liquid scintillation counter (LKB, Piscataway, NJ, USA).?These experiments were repeated at least 4 times[1]. |
| 別名 | CF-101, IB-MECA |
| 分子量 | 510.29 |
| 分子式 | C18H19IN6O4 |
| CAS No. | 152918-18-8 |
存儲(chǔ)
| Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 45 mg/mL (88.19 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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